No one from a group of 4,123 potentially Ebola-exposed individuals in the West African country of Guinea developed the disease after receiving a trial vaccine, a group of health authorities announced Friday, one of the most promising developments yet in the effort to eradicate the disease. Here’s more detail on the trial from the Lancet:
Between April 1, 2015, and July 20, 2015, 90 clusters, with a total population of 7651 people were included in the planned interim analysis. 48 of these clusters (4123 people) were randomly assigned to immediate vaccination with rVSV-ZEBOV, and 42 clusters (3528 people) were randomly assigned to delayed vaccination with rVSV-ZEBOV. In the immediate vaccination group, there were no cases of Ebola virus disease with symptom onset at least 10 days after randomisation, whereas in the delayed vaccination group there were 16 cases of Ebola virus disease from seven clusters, showing a vaccine efficacy of 100% (95% CI 74·7–100·0; p=0·0036). No new cases of Ebola virus disease were diagnosed in vaccinees from the immediate or delayed groups from 6 days post-vaccination.
Said a Doctors Without Borders official in a statement: “Even if the sample size is quite small and more research and analysis is needed, the enormity of the public health emergency should lead us to continue using this vaccine right now to protect those who might get exposed to the disease.”
There were seven new Ebola cases reported in West Africa in the most recent week for which data is available. More than 11,000 people have died in total from the disease during an outbreak that began last year.